Aquaporin-4 Autoimmunity Can Cause Exclusive Brain Tumefactive Lesions
نویسندگان
چکیده
منابع مشابه
Aquaporin-4 autoimmunity
Neuromyelitis optica (NMO) and a related spectrum of inflammatory CNS disorders are unified by detection of a serum autoantibody specific for the aquaporin-4 (AQP4) water channel, which is abundant in astrocytic foot processes. The classic clinical manifestations of NMO are optic neuritis and longitudinally extensive transverse myelitis. Newly recognized manifestations of AQP4 autoimmunity incl...
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Background: Neuromyelitis Optica Spectrum Disorder (NMOSD) is an autoimmune neurological disorder that is characterized by optic neuritis and longitudinally-extended transverse myelitis lesions in spinal segments. Magnetic Resonance Imaging (MRI) findings are part of the diagnostic process in NMOSD patients, and abnormal lesion patterns may cause deviation from a correct diagnosis. Clinical P...
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A 54-year-old woman with no medical history presented with left hemiparesis and hemianopsia. Brain MRI showed an extensive lesion without enhancement in the right parietal lobe, followed by rapid cavity formation (figure 1). Brain biopsy performed 55 days after disease onset revealed decreased glial fibrillary acidic protein and aquaporin-4 (AQP4) immunoreactivity, though we could not show the ...
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Opticospinal multiple sclerosis (OSMS) in Asians has similar features to the relapsing-remitting form of neuromyelitis optica (NMO) seen in Westerners. OSMS is suggested to be NMO based on the frequent detection of specific IgG targeting aquaporin-4 (AQP4), designated NMO-IgG. The present study sought to clarify the significance of anti-AQP4 autoimmunity in the whole spectrum of MS. Sera from 1...
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A 10-year-old girl presented with subacute lower limb weakness and gait ataxia. MRI revealed a large multicystic spinal cord lesion with patchy enhancement (figure 1, A and B) and 3 small (,6 mm) periventricular and deep white matter brain lesions. The presence of serum anti-aquaporin-4 (AQP4) immunoglobulin G (ELISA assay) and compatible neuropathologic features from neurosurgical specimens (f...
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ژورنال
عنوان ژورنال: Internal Medicine
سال: 2011
ISSN: 0918-2918,1349-7235
DOI: 10.2169/internalmedicine.50.6222